Polynucleotides (PN) | Featuring Ameela® + Plinest®
Polynucleotide treatments are one of the most exciting developments in regenerative aesthetics. Rather than simply “filling” or “freezing,” they work by supporting the skin’s own repair and renewal processes—making them particularly suitable for patients seeking natural, long-term skin improvement.
At Peonia Medical, we use clinically established brands including Ameela® and Plinest®, with Ameela Face® being a popular choice for facial rejuvenation.
What Are Polynucleotides Good For?
Polynucleotides (PN) are highly purified DNA fragments that act at a cellular level to:
- Stimulate fibroblasts (collagen-producing cells)
- Improve skin hydration and elasticity
- Support tissue repair and reduce inflammation
- Enhance overall skin quality and resilience
They are commonly used for:
- Fine lines and early skin ageing
- Dull, dehydrated or thinning skin
- Acne scarring and skin texture irregularities
- Delicate areas such as under-eyes and neck
- Skin recovery after laser or aesthetic procedures
Unlike dermal fillers, PN treatments do not add volume—they improve the quality of the skin itself.
Are There Any Allergy Risks?
Polynucleotides used in products such as Ameela® and Plinest® are highly purified and biocompatible, meaning:
- The risk of allergic reaction is extremely low
- No routine allergy testing is required
- They are well tolerated even in sensitive skin
However, as with any injectable treatment, a full medical consultation is essential to assess suitability and minimise risk.
What Happens on the Day of Treatment?
Your treatment will be carried out in a clinical setting by a medically trained practitioner.
Typical appointment flow:
- Consultation & skin assessment
- Cleansing and numbing (if required)
- Precise micro-injections into targeted areas
- Post-treatment soothing and aftercare advice
Duration:
- Approximately 30–45 minutes in total
Immediate Effects
After treatment, it is normal to experience:
- Small raised bumps at injection points (typically settle within 24–48 hours)
- Mild redness or swelling
- Occasional light bruising
Most patients return to normal activities either the same day or the following day.
Long-Term Results
Polynucleotides work gradually by improving skin function over time.
You can expect:
- Improved hydration and glow within a few weeks
- Progressive collagen stimulation over 4–8 weeks
- Stronger, healthier skin with better elasticity
- Subtle but natural-looking rejuvenation
For optimal results, a course of 2–3 sessions spaced 3–4 weeks apart is usually recommended, followed by maintenance treatments.
Why We Use Ameela® and Plinest®
At Peonia Medical, we select products based on clinical evidence, safety, and consistency.
- Ameela Face®: Known for its refined formulation and excellent tissue integration, particularly suited for facial rejuvenation and delicate areas
- Plinest®: A well-established PN range with strong regenerative properties, often used for both face and body indications
Both brands align with our philosophy of supporting skin health, not just altering appearance.
Is This Treatment Right for You?
Polynucleotide therapy is ideal if you are looking for:
- A natural, regenerative approach
- Subtle improvement rather than dramatic change
- Long-term skin quality enhancement
If you are currently undergoing other treatments, we can also integrate polynucleotides into a personalised plan to optimise healing and maintain results.
If you would like to explore whether this treatment is suitable for your skin, our team would be happy to guide you through a tailored consultation.